All participants are followed up according to the National Guidelines for patients with Colorectal Liver Metastases. All patients are controlled with a CT scan of the chest and abdomen and blood level of tumour antigen CEA. In Norway this is performed every 4 months the first year and further every 6 months. In Sweden the patients are controlled every 6 months. All controls are performed at the local hospitals, but the results are submitted to the ASAC trial centre to be registered in the electronic CRF. Once a year (every 12 months) the participants will be controlled at the ASAC trial centre and also receive next years study medication.